New Research Articles Published
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
Source: Visit https://www.bmj.com/content/368/bmj.m1091
Tao Chen, doctor, Di Wu, doctor, Huilong Chen, doctor, Weiming Yan, research associate, Danlei Yang, doctor, Guang Chen, doctor, Ke Ma, doctor, Dong Xu, doctor, Haijing Yu, doctor, Hongwu Wang, doctor, Tao Wang, doctor, Wei Guo, doctor, Jia Chen, doctor, Chen Ding, doctor, Xiaoping Zhang, doctor, Jiaquan Huang, doctor, Meifang Han, doctor, Shusheng Li, doctor, Xiaoping Luo, doctor4, Jianping Zhao, doctor, Qin Ning, doctor
Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Emergency Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China Department of Paediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.m1091 (Published 26 March 2020) Cite this as: BMJ 2020;368:m1091
https://www.bmj.com/content/368/bmj.m1091
Correspondence to: Q Ning qning@vip.sina.com
Accepted 17 March 2020
Abstract
Objective To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died.
Design Retrospective case series.
Setting Tongji Hospital in Wuhan, China.
Participants Among a cohort of 799 patients, 113 who died and 161 who recovered with a diagnosis of covid-19 were analysed. Data were collected until 28 February 2020.
Main outcome measures Clinical characteristics and laboratory findings were obtained from electronic medical records with data collection forms.
Results The median age of deceased patients (68 years) was significantly older than recovered patients (51 years). Male sex was more predominant in deceased patients (83; 73%) than in recovered patients (88; 55%). Chronic hypertension and other cardiovascular comorbidities were more frequent among deceased patients (54 (48%) and 16 (14%)) than recovered patients (39 (24%) and 7 (4%)). Dyspnoea, chest tightness, and disorder of consciousness were more common in deceased patients (70 (62%), 55 (49%), and 25 (22%)) than in recovered patients (50 (31%), 48 (30%), and 1 (1%)). The median time from disease onset to death in deceased patients was 16 (interquartile range 12.0-20.0) days. Leukocytosis was present in 56 (50%) patients who died and 6 (4%) who recovered, and lymphopenia was present in 103 (91%) and 76 (47%) respectively. Concentrations of alanine aminotransferase, aspartate aminotransferase, creatinine, creatine kinase, lactate dehydrogenase, cardiac troponin I, N-terminal pro-brain natriuretic peptide, and D-dimer were markedly higher in deceased patients than in recovered patients. Common complications observed more frequently in deceased patients included acute respiratory distress syndrome (113; 100%), type I respiratory failure (18/35; 51%), sepsis (113; 100%), acute cardiac injury (72/94; 77%), heart failure (41/83; 49%), alkalosis (14/35; 40%), hyperkalaemia (42; 37%), acute kidney injury (28; 25%), and hypoxic encephalopathy (23; 20%). Patients with cardiovascular comorbidity were more likely to develop cardiac complications. Regardless of history of cardiovascular disease, acute cardiac injury and heart failure were more common in deceased patients.
Conclusion Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk. Acute respiratory distress syndrome and respiratory failure, sepsis, acute cardiac injury, and heart failure were the most common critical complications during exacerbation of covid-19.